Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination ResponseSARS-CoV-2 감염 및 백신 접종 반응에 대한 암 환자의 감수성을 예측하기 위한 잠재적 도구로서의 MicroRNAReview Published on 2022-07-232022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Antiviral Biomarkers Cancer Cancer patients caused cellular processes contagious COVID-19 Defense deregulated deregulation described disease dysregulated expression genetic information global pandemic human infection immune immune response impair Infection Infectious disease key factor malignancies miR-223-3p miRNA miRNA profile miRNAs mRNA vaccine mRNAs Potential prognostic biomarker Regulation response SARS-CoV-2 SARS-CoV-2 replication Seven spike glycoproteins Spread treatment strategy Vaccine vaccine. Vaccines [DOI] 10.3390/cells11152279 PMC 바로가기 [Article Type] Review
Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired TranscriptionCOVID-19 폐 부검 표본의 다중 디자인 차등 발현 프로파일링은 상당히 규제 완화된 염증 경로 및 SFTPC 손상된 전사를 나타냅니다Article Published on 2022-03-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] Activation Autopsy carried cathepsin Cathepsin C CD163 CFB Clinical diagnosis complement Complement activation controls COVID-19 COVID-19 patient COVID-19-related death CTSC deaths deregulation develop differential expression effective effective therapy FFPE formalin formalin-fixed paraffin-embedded Gene expression profiling had no high viral load IFIT1 immune signature immunohistochemistry Impaired Inflammation ISG15 lung lung damage Macrophage macrophage polarization mechanism MS4A4A Nasopharyngeal swab OAS1 overexpression paraffin pathway pharmacological strategies PKM positive potential therapeutic targets Prevent probe Profiling Protein protein C pulmonary viral quantified required Respiratory disease RNA RNA-Seq RSAD2 SARS-CoV-2 SARS-COV-2 infection selected Seven SFTPC Siglec-1 SIGLEC1 signaling pathway specimen tissue sample tissue samples transcriptomic transcriptomic profiling. type I interferon Viral load were used [DOI] 10.3390/cells11061011 PMC 바로가기 [Article Type] Article
Role of Body Mass and Physical Activity in Autonomic Function Modulation on Post-COVID-19 Condition: An Observational Subanalysis of Fit-COVID StudyObservational Study Published on 2022-02-212022-10-04 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] activity acute SARS-CoV-2 infection Adults autonomic Autonomic nervous system BMI Body body mass index change changes in control group coronavirus disease COVID-19 cross-sectional deregulation detrimental Effect endothelial function evaluated exercise function healthy control heart rate inactive infected with SARS-CoV-2 infection with SARS-CoV-2 mass Mild-to-moderate modulate modulated Multiorgan nervous system obesity overweight/obese parasympathetic participant physical activity physical activity level physical activity levels physically promote recruited reduced role significantly higher significantly increased significantly lower Stress subject the disease Variability was increased were assessed [DOI] 10.3390/ijerph19042457 PMC 바로가기 [Article Type] Observational Study
Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill PatientsMedicine Published on 2022-02-032022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory distress syndrome addition adverse events analysis Analysis analyzed AUC BAS bioinformatics Biomarker bronchial Coagulation Cohort Combination composed COVID-19 Critical Critically ill critically ill patients deregulation enrichment analysis fibrosis first symptom FIVE high risk host miRNA profile ICU identify Ill immune response implicated IMPROVE IMV induce Inflammation Invasive mechanical ventilation involved mechanical ventilation microRNA miRNA miRNA profile miRNA signature molecular Mortality multivariable analysis Non-COVID-19 non-COVID-19 patient non-survivor nonsurvivor outcome pathological mechanism pathophysiology pathway Patient patient population performed Profiling prognostic biomarker Prospective Study Result RT-qPCR SARS-CoV-2 signature Stratification study population survival survivor the disease to define viral infections [DOI] 10.3389/fmed.2021.756517 PMC 바로가기 [Article Type] Medicine
The potential role of COVID-19 in the induction of DNA damageDNA 손상 유도에서 COVID-19의 잠재적 역할Review Published on 2022-01-012022-09-11 Journal: Mutation research. Reviews in mutation research [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting appearance Atherosclerosis Brain Cancer caused Cell cell cycle chronic disease Chronic diseases coronavirus coronavirus disease Coronavirus-2 Coronaviruses COVID-19 Cytokine storm syndrome death deregulation diabetes direct viral infection DNA DNA damage DNA repair DNA repair mechanism Effect Evidence evidence of genomic Health heart immunological in some individuals induce kidney kidneys Lungs mammalian cells mechanism multiorgan failure neurodegenerative disorders organs outcome Recovered COVID-19 patients recovered patient recovered patients Replication SARS-CoV-2 SARS-CoV-2. Sepsis Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Support Symptoms these viruses viral infection virus [DOI] 10.1016/j.mrrev.2022.108411 PMC 바로가기 [Article Type] Review
Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico AnalysisArticle Published on 2021-11-292022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] Altered coded coding gene COVID-19 COVID-19 patients CRISPR deregulated deregulation expression Factor functional Gene Expression IFN treatment interferon IRFs joint lncRNA Long long non-coding RNA majority manuscript mechanism modulate modulated MYC NFκB over pathogenesis of COVID-19 pathway Pathways PCG Protein Proteins Regulation resources RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-COV-2 infection significantly STATs target TFS tissue Transcription transcription factor transcription factors transcriptional regulation [DOI] 10.3390/ncrna7040074 PMC 바로가기 [Article Type] Article
A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19Article Published on 2021-11-252022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] affected amplifying antagonist anti-inflammatory agent anti-inflammatory response bind Cancer cause cirrhosis complex Corticosteroid COVID-19 Critical deregulation Dexamethasone disease Diseases expressed Factor gene expression level glucocorticoid HCC healthy subjects Hepatocellular carcinoma Human identify immunology IMPROVE Inflammation isoform knowledge liver Liver disease mice Molecular biology mRNA level NF-kB opposite p65 Patient PBMC physiological quantified receptor Regulation SARS-CoV-2 disease therapeutic target Transcription transcription factor transcription factors variant wild type [DOI] 10.1038/s41598-021-02119-z PMC 바로가기 [Article Type] Article
Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute InfectionArticle Published on 2021-11-222022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] CD4+ T-cell cells Coronavirus disease 2019 COVID-19 cytokine level cytokine response Cytokines death demonstrated deregulation effector events excessive inflammation exhausted/senescent T cells expression Frequency hallmark Ill immune system immunodeficiency immunopathology immunopathology. infected patient mechanism phenotype Reinfection Respiratory failure response SARS-CoV-2 severe pneumonia significantly increased susceptibility T cell T-cell T-cell exhaustion the cytokine storm [DOI] 10.1093/infdis/jiab425 PMC 바로가기
Hypertension and its management in COVID-19 patients: The assorted viewReview Article Published on 2021-11-132022-10-30 Journal: International Journal of Cardiology. Cardiovascular Risk and Prevention [Category] COVID-19, [키워드] ACE2 ACEi ACEIs Ang II angiotensin receptor blocker angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor ARB ARBs articles association binding cardiovascular disease carried Coagulopathy Complication Coronavirus disease 2019 COVID-19 COVID-19 severity CVD database Deleterious deregulation down-regulation Endothelial dysfunction Google Scholar hypertension hypertensive hypertensive patient hypertensive patients increase independent risk factor management objective Patient Protective RAAS reduction Result SARS-CoV-2 Serum level subsequent Web of Science with COVID-19 [DOI] 10.1016/j.ijcrp.2021.200121 PMC 바로가기 [Article Type] Review Article